HMGB1 released from neurons and proinflammatory microglia and has been attributed to both TBI and epilepsy pathogenesis in experimental models as reviewed by Paudel et al., 2018
Still, the growing intersection between metabolic and neurological research may reshape future therapeutic approaches
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In humans, cyanocobalamin must undergo intracellular enzymatic conversion to the active coenzyme formsmethylcobalamin and adenosylcobalaminwhich, depending on the pH environment, can interconvert with hydroxocobalamin (Gherasim et al., 2013), the most common B12 form in both food and human plasma (Obeid et al., 2015)
In addition, studies of bariatric surgery in overweight or obese individuals versus matched controls also showed decreased incidence of obesity-related cancers and decreased cancer-related mortality